1）Framework1.1是32位的程序，Framework2.0以上才支持了64位。

2）但是可以通过WOW64方式运行32位的Framework1.1。

3） 首先要保证64位的win2003安装了SP1。

4）使用命令cscript.exe adsutil.vbs set W3SVC/AppPools/Enable32BitAppOnWin64 “true”配置IIS。

5）当然要发挥64位性能的话，可以把你的web应用程序升级到Framework2.0以上。

 

原文地址：

Running 32-bit Applications on 64-bit Windows (IIS 6.0)

Windows Server 2003™, Service Pack 1 enables IIS 6.0 to run 32-bit Web applications on 64-bit Windows using the Windows-32-on-Windows-64 (WOW64) compatibility layer. IIS 6.0 using WOW64 is intended to run 32-bit personal productivity applications needed by software developers and administrators, including 32-bit Internet Information Services (IIS) Web applications.

On 64-bit Windows, 32-bit processes cannot load 64-bit DLLs, and 64-bit processes cannot load 32-bit DLLs. If you plan to run 32-bit applications on 64-bit Windows, you must configure IIS to create 32-bit worker processes. Once you have configured IIS to create 32-bit worker processes, you can run the following types of IIS applications on 64-bit Windows:

•	Internet Server API (ISAPI) extensions
•	ISAPI filters
•	Active Server Page (ASP) applications (specifically, scripts calling COM objects where the COM object can be 32-bit or 64-bit)
•	ASP.NET applications

IIS can, by default, launch Common Gateway Interface (CGI) applications on 64-bit Windows, because CGI applications run in a separate process.

 

To enable IIS 6.0 to run 32-bit applications on 64-bit Windows

1.	Open a command prompt and navigate to the %systemdrive%"Inetpub"AdminScripts directory.
2.	Type the following command: cscript.exe adsutil.vbs set W3SVC/AppPools/Enable32BitAppOnWin64 “true”
3.	Press ENTER.